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Uso de sulfametoxazol trimetoprima, sulfamethoxazole, and trimethoprim-sulfamethoxazole, but not fluoroquinolone antibiotics were found in all four studies [14–17]. Sulfamethoxazol and trimethoprim/sulfamethoxazole have been shown (with only three studies, one of fluoroquinolone antibiotics, and an open label two large clinical trials) to be non–clinically effective in children treated with trimethoprim/sulfamethoxazole [14–17]. In addition to the studies of sulfa, azithromycin, erythromycin, and tetracycline only two studies of tetracyclines and erythromycin sulfa were found in the reviewed cohort. An evaluation of azithromycin sulfa by Sabin et al. [19] reported that in an 8 year-old girl with cystic fibrosis, fluoroquinolone-antibiotic treatment did not significantly improve renal function (measured on creatinine, hemoglobin concentrations and hematologic parameters). However, Sabin et al. [19] also reported favorable renal effects in 13-17 year-old boys who received 2 grams three times per day of azithromycin sulfa in the treatment of cystic fibrosis. However, the results of this study are equivocal. An eight year-old boy treated with fluoroquinolones for 6 months had significant improvement in pulmonary function measurements (measured percentage of CFQF > 80) compared with placebo. A second study, by De Stefano et al., [20] also demonstrated improvement in pulmonary function patients with cystic fibrosis treated antibiotics such as fluoroquinolones. This improvement is consistent with findings in earlier studies that have shown improvement in pulmonary function with short-term fluoroquinolone therapy [21]. Two additional small studies showed improvement in respiratory infections (chorioamnionitis and bronchitis) with short term fluoroquinolone treatment of 2–5 grams per day [22, 23]. Both studies failed to demonstrate a change in hemoglobin concentration or hemagglutination inhibition (AI). Overall, these findings suggest that short duration fluoroquinolone treatment is acceptable for the of cystic fibrosis. 3.2. Dalfampridine (Solfoton) A randomized trial with 531 cystic fibrosis patients demonstrated modest improvement of cystatin in the cystic fibrosis group versus placebo over 8 week treatment period [24] and further showed a significant improvement in cystic fibrosis patients who received 10 grams or 20 of Dalfampridine sulfa in combination with a cefazolin sulfate and penicillin monotherapy versus placebo treatment over six months [25]. However, two small open label studies (two in 523 patients [26, 27]) and two large open label clinical trials (one study in 527 patients [28]) failed to show improvement in cystic fibrosis patients treated with Dalfampridine sulfa, in a dose or combination with fluoroquinolones, azithromycin, aztreonam, tetracycline, penicillin or cefazolin. Two small open label, one long-term, label and open clinical trial compared to placebo or a control arm in patients with cystic fibrosis treated by either an aztreonam or azithromycin sulfa regimen [29–31] and the results of all trials are equivocal. Two clinical study populations included in these studies children and adolescents, one of whom did not have cystic fibrosis. A study in adults by Marangoni et al. [30] showed no overall change in lung function with Dalfampridine sulfa treatment, treatment groups receiving either azide or dimethacrylate (as Como se usa la indometacina the sulfate salt) having comparable scores (measured using a respiratory function monitoring device) to patients treated with placebo. A study by Marangoni et al. [30] noted beneficial responses during therapy in patients treated with fluoroquinolones, azithromycin or cefazolin aztreonam, dalfampridine and aztreonam [30]. Furthermore, sulfa showed benefit in patients with severe cystic fibrosis using the Endoscopic Monitoring (CFEEMON®) scoring system, Atorvastatin 40 mg kaufen and CFEEMON® showed a significant improvement in response to the cefazolin sulfate dose [32, 33]. However, a CFEEMON® was not used in the short term trials; results are equivocal. 3.3. Amoxicillin and Clavulanate The most frequently used antibiotics in cystic.
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